Foundations

Neuromethods

The computational engine behind the science.

Overview

We build the core computational methods that power the lab's work, from fractal geometry and deep learning to signal processing and the infrastructure that turns data into discovery.

Neuromethods is the methodological engine of the lab, the place where the algorithms, models and infrastructure that power everything else are developed and refined. Rather than being tied to a single clinical question, this domain builds the general-purpose computational tools that our imaging, pathology and surgical work depend on. A signature strand is fractal geometry, a long-standing line of the lab's work that quantifies the self-similar complexity of the brain and its structures, from vasculature to tumours. Alongside this we develop deep-learning architectures, signal-processing methods for neural data such as MEG, and the frameworks, including transfer learning, generative and foundation-model approaches, that let models learn effectively from the limited, heterogeneous data typical of clinical neuroscience. This domain also encompasses the computational resources and pipelines that make the science reproducible and scalable, from local high-performance compute to national supercomputing infrastructure.

Methods

Techniques & approaches

The computational methods that underpin this research area

Radiomics

Fractal geometry, Deep learning architectures, Signal processing (MEG/EEG), Transfer and foundation models, Algorithm development, High-performance computing

Publications

Selected publications in this area

Journal article

2024

Adaptive unified contrastive learning with graph-based feature aggregator for imbalanced medical image classification

Cong C., Liu S., Rana P., Pagnucco M., Di Ieva A., Berkovsky S., Song Y.

Expert Systems with Applications

Conference paper

2024

Adaptive unified contrastive learning for imbalanced classification

Cong C., Yang Y., Liu S., Pagnucco M., Di Ieva A., Berkovsky S., Song Y.

Machine Learning in Medical Imaging

Journal article

2024

A Deep Learning Methodology for Differentiating Glioma Recurrence from Radiation Necrosis using Multimodal MRI: Algorithm Development and Validation (Preprint)

Gao Y., Xiao X., Han B., Li G., Ning X., Wang D., Cai W., Kikinis R., Berkovsky S., Ieva A.D., Zhang L., Ji N., Liu S.

JMIR Medical Informatics

Book chapter

2024

Fractals in neuroanatomy and basic neurosciences: an overview

Di Ieva A.

The fractal geometry of the brain

Funding

Selected funding in this area

Grants supporting our computational neuroimaging research programme

Macquarie University

Biomedical mass spectrometry system

$1,000,000

Research Infrastructure Scheme

Department of Industry, Science and Resources (Commonwealth)

Quantum MEG scanner design and development (Stage 1)

$187,560

Critical Tech Challenge

Macquarie University

Bruker timsTOF Pro mass spectrometer

$150,000

Research Infrastructure Scheme

Macquarie University

Foundation models to transform biological research

$50,000

BioInnoMQ

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