Foundations
Neuromethods
The computational engine behind the science.

Overview
Neuromethods is the methodological engine of the lab, the place where the algorithms, models and infrastructure that power everything else are developed and refined. Rather than being tied to a single clinical question, this domain builds the general-purpose computational tools that our imaging, pathology and surgical work depend on. A signature strand is fractal geometry, a long-standing line of the lab's work that quantifies the self-similar complexity of the brain and its structures, from vasculature to tumours. Alongside this we develop deep-learning architectures, signal-processing methods for neural data such as MEG, and the frameworks, including transfer learning, generative and foundation-model approaches, that let models learn effectively from the limited, heterogeneous data typical of clinical neuroscience. This domain also encompasses the computational resources and pipelines that make the science reproducible and scalable, from local high-performance compute to national supercomputing infrastructure.
Methods
Techniques & approaches
The computational methods that underpin this research area
Radiomics
Publications
Selected publications in this area
Journal article
2024
A Deep Learning Methodology for Differentiating Glioma Recurrence from Radiation Necrosis using Multimodal MRI: Algorithm Development and Validation (Preprint)
Gao Y., Xiao X., Han B., Li G., Ning X., Wang D., Cai W., Kikinis R., Berkovsky S., Ieva A.D., Zhang L., Ji N., Liu S.
JMIR Medical Informatics
Funding
Selected funding in this area
Grants supporting our computational neuroimaging research programme
Macquarie University
Biomedical mass spectrometry system
$1,000,000
Research Infrastructure Scheme
Department of Industry, Science and Resources (Commonwealth)
Quantum MEG scanner design and development (Stage 1)
$187,560
Critical Tech Challenge
Macquarie University
Bruker timsTOF Pro mass spectrometer
$150,000
Research Infrastructure Scheme
Macquarie University
Foundation models to transform biological research
$50,000
BioInnoMQ
Browse publications.
Join our work.
Explore the full body of CNS Lab research or contact us to discuss collaboration opportunities.