Structural

Computational Neurobiology & Neuroanatomy

Mapping the brain's architecture, from vessels to networks.

Overview

We study the brain's structure and biology computationally, including its microvasculature, neuroanatomy and molecular processes, to understand how form underlies function and disease.

Computational Neurobiology & Neuroanatomy applies the lab's quantitative methods to the fundamental structure and biology of the brain. Here the focus shifts from diagnosis and surgery to understanding: how the brain is built, how its architecture varies, and how structural and molecular changes underlie disease. Our work includes computational neuroanatomy and the analysis of microvascular networks, often through the lens of fractal and geometric complexity, as well as collaborations that reach into molecular and cellular biology, from tumour modelling to protein interactions and tissue engineering. By quantifying the brain's form across scales, we build the structural foundation on which functional and clinical interpretation rests. This domain is deliberately collaborative and cross-disciplinary, connecting the lab's computational strengths with experimental neurobiology at Macquarie University and partner institutions.

Methods

Techniques & approaches

The computational methods that underpin this research area

Radiomics

Computational neuroanatomy, Microvascular network analysis, Fractal morphometry, In vitro and tumour modelling, Molecular and cellular integration, Cross-disciplinary collaboration

Publications

Selected publications in this area

Journal article

2024

Distinctive features of the tumor and immune microenvironment in glioblastoma

Shklovskaya, E., Pedersen, B., Lim, S.Y., Irvine, M., Brown, J.R., Pinho, A.V., Shivalingam, B., Menzies, A.M., Satgunaseelan, L., Alexander, K.L. and Di Ieva, A.

NPJ Precision Oncology

Funding

Selected funding in this area

Grants supporting our computational neuroimaging research programme

Multiple industry sponsors

Brain Anatomy & White Matter dissection workshops

$200,000

Industry sponsorship

MND Research Australia

Characterising the interactome of sequestosome-1 (p62)

$100,000

Innovator Grant

Macquarie University

The elephant in the room: overlooked molecules in systems biology

$50,000

BioInnoMQ

Macquarie University

A magnetic multi-tool: pulsed magnetic fields for brain repair

$49,932

Research Fellowship Grant

Browse publications.

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Explore the full body of CNS Lab research or contact us to discuss collaboration opportunities.